ERBB-2 SELECTIVE SMALL MOLECULE KINASE INHIBITORS

摘要

A novel method for erbB-2 kinase inhibition by compounds identified throug h computational modeling and data processing and/or rational and de novo drug design is provided. The compounds bind erbB-2 kinase molecules and can be used as erbB -2 kinase agonists or antagonists. These compounds are useful especially in the treatment of cancer, particularly breast cancer.