| 发明名称 |
Compositions and methods for modifying toxic effects of proteinaceous compounds |
| 摘要 |
The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS.
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| 申请公布号 |
US7452971(B2) |
申请公布日期 |
2008.11.18 |
| 申请号 |
US20050263537 |
申请日期 |
2005.10.31 |
| 申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
VITETTA ELLEN S.;GHETIE VICTOR F.;SMALLSHAW JOAN E.;BALUNA ROXANA G. |
| 分类号 |
A61K38/00;A61K38/16;A61K38/19;A61K39/02;A61K39/395;C07K14/00;C07K14/415;C07K14/55;C07K16/46;C07K19/00;G01N |
主分类号 |
A61K38/00 |
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