PYRIDINE DERIVATIVE SUBSTITUTED WITH HETEROCYCLE AND PHOSPHONOAMINO AND ANTIFUNGAL AGENT CONTAINING THE SAME

摘要

An antifungal agent that has an excellent antifungal activity and excels in not only properties, especially solubility in water but also safety. There are disclosed compounds of the formula (I) and salts thereof. [in the formula, R<SUP>1</SUP> is a hydrogen atom, halogen atom, amino, R<SUP>11</SUP>-NH- (R<SUP>11</SUP> is a C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, hydroxylated C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, C<SUB>1</SUB>-C<SUB>6</SUB> alkoxylated C<SUB>1</SUB>-C<SUB>6</SUB> alkyl or C<SUB>1</SUB>-C<SUB>6</SUB> alkoxycarbonylated C<SUB>1</SUB>-C<SUB>6</SUB> alkyl), R<SUP>12</SUP>-(CO)-NH- (R<SUP>12</SUP> is a C<SUB>1</SUB>-C<SUB>6</SUB> alkyl or C<SUB>1</SUB>-C<SUB>6</SUB> alkoxylated C<SUB>1</SUB>-C<SUB>6</SUB> alkyl), C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, hydroxylated C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, cyano C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, C<SUB>1</SUB>-C<SUB>6</SUB> alkoxy, C<SUB>1</SUB>-C<SUB>6</SUB> alkoxylated C<SUB>1</SUB>-C<SUB>6</SUB> alkyl or phosphonoamino; R<SUP>2</SUP> is a hydrogen atom, C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, amino, di-(C<SUB>1</SUB>-C<SUB>6</SUB> alkylamino) or phosphonoamino; either X or Y is a nitrogen atom while the other is a nitrogen atom or oxygen atom; the ring A is a 5- or 6-membered heteroaryl ring or benzene ring optionally having one or two C<SUB>1</SUB>-C<SUB>6</SUB> alkyls or halogen atoms; Z is a single bond, methylene,ethylene, oxygen atom, sulfur atom, -CH<SUB>2</SUB>O-, -OCH<SUB>2</SUB>-, -NH-, -CH<SUB>2</SUB>NH-, -NHCH<SUB>2</SUB>-, -CH<SUB>2</SUB>S- or -SCH<SUB>2</SUB>-; R<SUP>3</SUP> is a hydrogen atom, halogen atom, or optionally monosubstituted or disubstituted C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, C<SUB>3</SUB>-C<SUB>8</SUB> cycloalkyl, C<SUB>6</SUB>-C<SUB>10</SUB> aryl, 5- or 6-membered heteroaryl or 5- or 6-membered nonaromatic heterocycle; and R<SUP>4</SUP> is a hydrogen atom or halogen atom, provided that either R<SUP>1</SUP> or R<SUP>2</SUP> is phosphonoamino].