发明名称 |
SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES, WITH A COMBINATION OF COMPOUNDS, OR A BIFUNCTIONAL COMPOUND,THAT PROVIDES FATTY ACID METABOLISM AND GLYCOLYSIS INHIBITION |
摘要 |
Methods and compositions for treating inflammatory and proliferative diseases, enabling treatment of MDR tumor cells by using combination of compounds, or a bifunctional compound, that inhibits both fatty acid metabolism and glycolysis. In particular, the invention combines or links a glycolysis inhibitor that is, or that is derived from, hypoglycin A (also referred to as hypoglycine A) and a fatty acid metabolism inhibitor. Preferably, the invention provides bifunctional compounds that link a moiety having the functionality of an oxirane carboxylic acid compound to a moiety having the functionality a hypoglycin A derivative. In specific embodiments, the invention provides a bifunctional compound that links a moiety having the functionality of etomoxir to a moiety having the functionality of hypoglycin A.
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申请公布号 |
WO2006118821(A3) |
申请公布日期 |
2008.11.13 |
申请号 |
WO2006US15124 |
申请日期 |
2006.04.20 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO;NEWELL, M. KAREN, ROGERS;NEWELL, EVAN |
发明人 |
NEWELL, M. KAREN, ROGERS;NEWELL, EVAN |
分类号 |
A61K31/20 |
主分类号 |
A61K31/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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