PHOSPHATIDYLETHANOLAMINE DERIVATIVE AND LIPOSOME CONTAINING THE SAME

摘要

The present invention provides a liposome preparation having high efficiency of delivery of a drug into a target cell, which exhibits such an appropriate retention in blood as to allow the pharmaceutical preparation to be incorporated into a target cell but not such a long time as to induce its side effects on normal cells, as well as a novel synthetic phospholipid useful in preparation of the liposome preparation. Disclosed is a phosphatidylethanolamine derivative represented by the following general formula (1), or salts thereof: wherein X represents -0-, -NH- or -S-, R¹ represents an alkyl group, a cycloalkyl group or an aryl group, R² and R³ independently represent an acyl group, and m represents an integer of 1 to 10.