| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for stabilizing a polypeptide by formation of at least one bond, preferably a disulfide bond, between different domains of the polypeptide. <P>SOLUTION: The invention also relates to polypeptides in which one or more cysteine residues are introduced, polypeptides containing such introduced cysteine residue(s), nucleic acids encoding such polypeptides and pharmaceutical compositions comprising such polypeptides or nucleic acids. The invention also relates to vectors, viral particles and host cells containing such nucleic acids, and methods of using them to produce the polypeptides of the invention. Exemplified polypeptides include plasma proteins, including hepatocyte growth factor activator and plasma hyaluronin binding protein, as well as blood coagulation factors, such as Factor VIII, Factor V, Factor XII and prothrombin. <P>COPYRIGHT: (C)2009,JPO&INPIT |
