IMMUNOGLOBULIN FC LIBRARIES

摘要

Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferent ially bind to particular Fc receptors are described. Furthermore, the invent ion provides aglycosylated Fc domains that bind to Fc receptors with high af finity. Enhanced methods and media for prokaryotic based interaction screeni ng are also provided.