| 摘要 |
The present invention comprises a new class of compounds useful for the p rophylaxis and treatment of protein kinase mediated diseases, including infl ammation and related conditions. The compounds have general Formula (I) wher ein A1, A2, B, R1, R2, R4, R5, R6 and Z are defined herein. The invention al so comprises pharmaceutical compositions including one or more compounds of Formula (I), uses of such compounds and compositions for treatment of P38 ma p kinase mediated diseases including rheumatoid arthritis, psoriasis, chroni c obstructive pulmonary disease, pain and other inflammatory disorders, as w ell as intermediates and processes useful for the preparation of compounds o f Formula (I).
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