O-ALKYLATED RAPAMYCIN DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To provide an O-alkylated rapamycin derivative and a medical device using the derivative.

SOLUTION: The O-alkylated rapamycin derivative is obtained by reaction between rapamycin and an alkyl triflate in an organic solvent. One use of the derivative, specifically 40-O-[(2'-ethoxy)ethyl]rapamycin, is coating on a medical equipment such as stent. The coated stent is indwelled in a lesion such as blood vessel, so that the O-alkylated rapamycin derivative is uptaken into the lesion to prevent restenosis.

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