发明名称 Amines as Small Molecule Inhibitors
摘要 The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. Said compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
申请公布号 US2008280925(A1) 申请公布日期 2008.11.13
申请号 US20080039141 申请日期 2008.02.28
申请人 METHYLGENE INC. 发明人 WAHHAB AMAL;THERRIEN ERIC;ALLAN MARTIN;MANKU SUKHDEV
分类号 A61K31/415;A61K31/4155;A61K31/4184;A61K31/4245;A61K31/4439;A61K31/445;A61K31/454;A61K31/519;A61P29/00;A61P31/00;A61P35/00;A61P37/00;C07D211/30;C07D231/14;C07D235/04;C07D401/04;C07D401/10;C07D403/04;C07D413/02;C07D487/04;C12N5/00 主分类号 A61K31/415
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