ANTHRANILIC ACID DERIVATIVES AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF

摘要

The present invention provides novel anthranilic acid derivative useful as potential anticancer agent. More particularly, the present invention relates novel anthranilic acid derivative of general formula (8), R' = alkyl-2-methoxyphenyl piperazine (or) benzyl, R = 2 mthoxy phenyl, piperazine, 2-pyridyl piperazine, 2-pyrimidyl piperazine, 4-quinazolinyI piperazine, 9H-9-fluorenylamine, 4-{(2{amino-5-(methoxy)-4-[(phenylmethyl)oxy]phenyl} carbonyl)hexahydro-1-pyrazinyl], and [(4[2amino-4-(benzyloxy)-5-methoxybenzoyl] aminophenyI)sulfonyl]-4-benzamine; X = H (or) pyrazine-2-carbonyl. The present invention also provides a process for the preparation of novel anthranilic acid derivative of general formula (8), which is useful as potential anticancer agent.