| 摘要 |
Methods of delaying the onset or treating the progression of Type 2 diabetes in subjects that have increased blood levels of an inflammation marker protein. In one embodiment, the method includes administering an inhibitor OF alpha<SUB>1</SUB>-antitrypsin (AT) to the subject, and optionally co-administering an anti-diabetic medicament or anti-inflammatory agent to the subject. Treatment regimens provided by the invention may be used to delay the onset of or to control Type 2 diabetes. The invention provides for the use of an inhibitor of alpha<SUB>1</SUB>-antitrypsin, such as gemfibrozil (GF), for the manufacture of a medicament for the uses described herein. The invention further provides combinations of agents for treating or delaying the progression or onset of diabetes, comprising an inhibitor of alpha<SUB>1</SUB>-antitrypsin and an anti-inflammatory agent and/or an anti-diabetic medicament.
|
