5-Amino-4-Hydroxy-7-(1H-Indolmethyl)-8-Methylnonamide Derivatives as Renin Inhibitors for the Treatment of Hypertension

摘要

The application relates to novel alkanamides of the general formula (I) where X is -CH₂- or >CH-OH; (A) R¹ is e.g. an optionally substituted heterocyclyl radical or an optionally substituted polycyclic, unsaturated hydrocarbon radical where X is hydroxymethylene; R² is C₁-C₆-alkyl or C₃-C₆-cydoalkyl; R³ are each independently H, C₁-C₆-alkyl, C_1-6-alkoxycarbonyl or C₁-C₆-alkanoyl; R⁴ is C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₂-C₆-alkenyl or unsubstituted or substituted arylC₁-C₆-alkyl; R⁵ is C₁-C₆-alkyl, C₁-C₆-hydroxyalkyl, C₁-C₆-alkoxy-C₁-C₆-alkyl, C₁-C₆-alkanoyloxy C₁-C₆-alkyl, C₁-C₆-aminoalkyl, C₁-C₆-alkylamino-C₁-C₆-alkyl, C₁-C₆-dialkylamino-C₁-C₆-alkyl, C₁-C₆-alkanoylamido-C₁-C₆-alkyl, HO(O)C-C₁-C₆-alkyl, C₁-C₆-alkyl-O-(O)C-C₁-C₆-alkyl, H₂N-C(O)-C₁-C₆-alkyl, C₁-C₆-alkyl-HN-C(O)-C₁-C₆-alkyl, (C₁, -C₆-alkyl)₂N-C(O)-C₁-C₆-alkyl, C₂-C₈-alkenyl, C₂-C₈-alkynyl, cyano-C₁-C₆-alkyl, halo-C₁-C₆-alkyl, optionally substituted aryl-C_o-C₆-alkyl, optionally substituted C₃-C₈-cycloalkyl-C_o-C₆-alkyl or optionally substituted heterocydyl-C_o-C₆-alkyl; to a process for their preparation and to the use of these compounds as medicines, especially as renin inhibitors for the treatment of hypertension.