发明名称 |
DETECTING ISOMERS USING DIFFERENTIAL DERIVATIZATION MASS SPECTROMETRY |
摘要 |
<p>Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isome rs of branched-chain amino acids in a sample comprising a branched-chain ami no acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization, a nonderivatized or derivatized branched chain amino acid that is labeled with one or more heavy atoms, as a second s tandard; evaluating the sample using tandem mass spectrometry; and detecting peaks indicative of derivatized and nonderivatized forms of one or more bra nched-chain amino acids in the sample.</p> |
申请公布号 |
CA2686199(A1) |
申请公布日期 |
2008.11.13 |
申请号 |
CA20082686199 |
申请日期 |
2008.05.05 |
申请人 |
PERKINELMER HEALTH SCIENCES, INC. |
发明人 |
LI, YIJUN;CHERKASSKIY, ALEX;CERDA, BLAS |
分类号 |
B01L99/00;G01N33/48 |
主分类号 |
B01L99/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|