Antibiotics Derivatives

摘要

The invention relates to antibiotic derivatives of formula I wherein: A represents -O-, S, -C(-O)-, -C(-NOR⁶)-; Z-B represents NCH₂CH₂, NCOCH₂, NCH₂CO, NCH₂CH(OH), CHN(R⁸)CH₂ or CHN(R⁸)CO; D represents binuclear heteroaryl; Y¹ represents -CR¹- or -N-, Y² represents -CR²- or -N-, Y³ represents -CR³- or -N- and Y⁴ represents -CR⁴- or -N-; U represents -NH-, -O- or -S- and V represents -N- or -CH-; W represents -CH₂-, -O- or -NR⁷-; R¹ represents H, methyl, ethyl or halogen; R², R³ and R⁴ each represent independently H, C₁-C₄ alkyl, halogen, or C₁-C₄ alkoxy; R⁵ represents H, C₁-C₄ alkyl or fluorine; R⁶ represents H, C₁-C₄ alkyl or aryl-C₁-C₄ alkyl; R⁷ represents H, C₁-C₄ alkyl, aryl-C₁-C₄ alkyl or -CH₂-COOH; R⁸ represents H, C₁-C₄ alkyl or -CH₂-COOH; with the provisos that if Z-B represents NCH₂CH₂, NCOCH₂, NCH₂CO or NCH₂CH(OH), then W represents -CH₂-; if A represents O or S, then W represents -CH₂-; and only one or two of Y¹, Y², Y³ and Y⁴ can represent N at the same time.