OLIGOSACCHARIDES COMPRISING AN AMINOOXY GROUP AND CONJUGATES THEREOF
摘要
The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.
申请公布号
WO2008089403(A3)
申请公布日期
2008.11.13
申请号
WO2008US51429
申请日期
2008.01.18
申请人
GENZYME CORPORATION;ZHU, YUNXIANG;CHENG, SENG, H.;JIANG, CANWEN;AVILA, LUIS, Z.
发明人
ZHU, YUNXIANG;CHENG, SENG, H.;JIANG, CANWEN;AVILA, LUIS, Z.