SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF
摘要
The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active inhibitor moiety in proximity to a target protease. In certain instances, compounds inhibit proteasomes and/or post-proline cleaving enzymes (PPCE), such as dipeptidyl peptidase IV. The compounds of the invention provide a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.
申请公布号
WO2007100374(A3)
申请公布日期
2008.11.13
申请号
WO2006US47853
申请日期
2006.12.15
申请人
TRUSTEES OF TUFTS COLLEGE;LAI, HUNG-SEN;WU, WENGEN;BACHOVCHIN, WILLIAM, W.