发明名称 |
PROCESS FOR THE PREPARATION OF INSULIN CONJUGATES. |
摘要 |
<p>The invention claims a process for making an insulin-oligomer conjugate IN-105. IN-105 precursor having formula G-A-V-R-[B-Chain]-R-D-A-D-D-R-[A-Chain] is cloned and expressed in Pichia. The biosynthetic precursor is then conjugated with an activated oligomer. The IN-105 precursor-oligomer conjugate is then treated with protease and purified to afford active insulin-oligomer conjugate of formula insulin-OC-CH2-CH2-(OCH2CH<sub >2)3-OCH3.</p> |
申请公布号 |
MX2008004674(A) |
申请公布日期 |
2008.11.12 |
申请号 |
MX20080004674 |
申请日期 |
2005.10.13 |
申请人 |
BIOCON LIMITED |
发明人 |
PARTHA HAZRA;ANAND KHEDKAR;HARISH IYER;NITESH DAVE;GAUTAM KRISHNAN;SHRIKUMAR SURYANARAYAN;ANUJ GOEL;NITA ROY;H. S. MANJUNATH;GOVINDASAMY MANIKAM;GOLDY SACHDEV;MAYANK GARG |
分类号 |
C07K14/62 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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