Nukleinsyremikrokugler samt deres fremstilling og afgivelse

摘要

Microspheres comprising between 20 weight percent and 100 weight percent of one or more nucleic acids, and having an average particle size of not greater than about 50 microns, wherein said microspheres are substantially free of a water soluble polymer used in microsphere preparation, for use in therapy. Microspheres comprising between 20 weight percent and 100 weight percent of one or more nucleic acids, and having an average particle size of not greater than about 50 microns, wherein said microspheres are substantially free of a water soluble polymer used in microsphere preparation, for use in the treatment of an autoimmune disease. Use of microspheres comprising between 20 weight percent and 100 weight percent of one or more nucleic acids, and having an average particle size of not greater than about 50 microns, wherein said microspheres are substantially free of a water soluble polymer used in microsphere preparation, in the manufacture of a medicament for the treatment of an autoimmune disease.