摘要 |
Process for the preparation of phosphatidylserine of formula wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>independently represent a saturated, mono-unsaturated or polyunsaturated acyl C<SUB>10</SUB>-C<SUB>30</SUB>, X-OH or OM where M=alkaline or alkaline earth metal, ammonium, alkylammonium (including the inner salt) including the transphosphatidylation reaction between phosphatidylcholine of the general formula wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>and X have the above specified meanings, R<SUP>3</SUP>-CH<SUB>2</SUB>-CH<SUB>2</SUB>-NH<SUB>2 </SUB>o CH<SUB>2</SUB>-CH<SUB>2</SUB>-N<SUP>+</SUP>(CH<SUB>3</SUB>)<SUB>3 </SUB>and Serine in D, L or racemic form catalysed by the phospholipase D enzyme (PLD), characterised in that said reaction is carried out in a hydroalcoholic medium containing an aliphatic alcohol and in the presence of bivalent metal oxide.
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