发明名称 |
PHARMACEUTICAL USE OF SUBSTITUTED AMIDES |
摘要 |
<p>The use of substituted amides for modulating the activity of 11ß-hydroxysteroid dehydro-genase type 1 (11ßHSD1) and the use of these compounds as pharmaceutical composi-tions, are described. Also a novel class of substituted amides, their use in therapy, phar-maceutical compositions comprising the compounds, as well as their use in the manufac-ture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11ßHSD1 and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active gluco-corticoid is desirable.</p> |
申请公布号 |
WO2008134221(A1) |
申请公布日期 |
2008.11.06 |
申请号 |
WO2008US59903 |
申请日期 |
2008.04.10 |
申请人 |
TRANSTECH PHARMA, INC.;NOVO NORDISK A/S;EBDRUP, SOREN;ANDERSEN, HENRIK, SUNE |
发明人 |
EBDRUP, SOREN;ANDERSEN, HENRIK, SUNE |
分类号 |
A01N37/12;A01N37/44;A61K31/195 |
主分类号 |
A01N37/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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