发明名称 |
INHIBITORS OF NUCLEOPHOSMIN (NPM) AND METHODS FOR INDUCING APOPTOSIS |
摘要 |
Nucleophosmin inhibitors are disclosed which inhibit the multimerization of nucleophosmin and the biological activity of nucleophosmin, such as the ability of nucleophosmin to inhibit apoptosis and inhibit cellular differentiation. These small molecule inhibitors are useful for treating diseases and disorders, such as cancer associated with dysregulated nucleophosmin expression. Methods for identifying small molecule inhibitors of nucleophosmin involving multimerization sites for nucleophosmin are also disclosed. An exemplary small molecule inhibitor of nucleophosmin is NSC348884 which has the following chemical structure.
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申请公布号 |
WO2008106594(A3) |
申请公布日期 |
2008.11.06 |
申请号 |
WO2008US55302 |
申请日期 |
2008.02.28 |
申请人 |
MAHADEVAN, DARUKA;QI, WENQUING;OLENYUK, BOGDAN |
发明人 |
MAHADEVAN, DARUKA;QI, WENQUING;OLENYUK, BOGDAN |
分类号 |
A61K31/40;A61K39/395;C07D401/00;C09B5/00 |
主分类号 |
A61K31/40 |
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