发明名称 |
Framework Residue Substituted Humanized Col-1 Antibodies and Their Use |
摘要 |
The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.
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申请公布号 |
US2008274055(A1) |
申请公布日期 |
2008.11.06 |
申请号 |
US20050813092 |
申请日期 |
2005.12.30 |
申请人 |
KASHMIRI SYED;KASHMIRI RAFIA MEHDI;SCHLOM JEFFREY;PADLAN EDUARDO A |
发明人 |
KASHMIRI SYED;KASHMIRI RAFIA MEHDI;SCHLOM JEFFREY;PADLAN EDUARDO A. |
分类号 |
A61K39/395;A61K49/00;A61P35/00;C07K16/30;C12N5/10;C12N15/13;C12N15/79;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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