发明名称 |
NUCLEIC ACID COMPOUNDS FOR INHIBITING MAP2K GENE EXPRESSION AND USES THEREOF |
摘要 |
<p>The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing MAP2K (e.g., MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7) gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a MAP2K mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine, a nucleoside replaced with a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of a MAP2K gene in a cell or in a subject to treat a MAP2K-related disease.</p> |
申请公布号 |
WO2008109353(B1) |
申请公布日期 |
2008.11.06 |
申请号 |
WO2008US55340 |
申请日期 |
2008.02.28 |
申请人 |
MCSWIGGEN, JAMES;MDRNA, INC.;QUAY, STEVEN, C.;VAISH, NARENDRA, K.;AHMADIAN, MOHAMMAD |
发明人 |
QUAY, STEVEN, C.;MCSWIGGEN, JAMES;VAISH, NARENDRA, K.;AHMADIAN, MOHAMMAD |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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