发明名称 |
DUAL-ACTING ANTIHYPERTENSIVE AGENTS |
摘要 |
The invention is directed to compounds having the formula: (I) wherein: A r, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharm aceutically acceptable salts thereof. These compounds have AT1 receptor anta gonist activity and neprilysin inhibition activity. The invention is also di rected to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compo unds. |
申请公布号 |
CA2682508(A1) |
申请公布日期 |
2008.11.06 |
申请号 |
CA20082682508 |
申请日期 |
2008.04.23 |
申请人 |
THERAVANCE, INC. |
发明人 |
GENDRON, ROLAND;FATHEREE, PAUL R.;MCKINNELL, ROBERT MURRAY;MCMURTRIE, DARREN;JENDZA, KEITH;CHOI, SEOK-KI;OLSON, BROOKE;ALLEGRETTI, PAUL |
分类号 |
C07D213/64;A61K31/4164;A61K31/4178;A61K31/4412;A61P9/00;C07D233/64;C07D233/68;C07D233/70;C07D401/10;C07D401/12;C07D409/06 |
主分类号 |
C07D213/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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