LIVE VACCINE CONTAINING ATTENUATED AVIRULENT STRAIN OF LAWSONIA INTRACELLULARIS

摘要

PROBLEM TO BE SOLVED: To provide a method of a large scale cultivation of Lawsonia intracellularis, its avirulent attenuated strain, its manufacturing process, and a live vaccine containing Lawsonia intracellularis using the cultured bacteria obtained. SOLUTION: Cultured cells are inoculated with Lawsonia intracellularis bacteria and incubated in a reduced oxygen concentration, and the infected cells are maintained in suspension and cultured. The avirulent Lawsonia intracellularis strain is obtained by passageing the infected cells. COPYRIGHT: (C)2009,JPO&INPIT