RECOMBINANT VITAMIN K DEPENDENT PROTEINS WITH HIGH SIALIC ACID CONTENT AND METHODS OF PREPARING SAME
摘要
Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N- glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.
申请公布号
WO2008134665(A1)
申请公布日期
2008.11.06
申请号
WO2008US61822
申请日期
2008.04.28
申请人
INSPIRATION BIOPHARMACEUTICALS,INC;GRIFFITH, MICHAEL, J.;DROHAN, MARIAN, J.
发明人
GRIFFITH, MICHAEL, J.;DROHAN, MARIAN, J.;DROHAN, WILLIAM, N.