发明名称 |
NOVEL POOLING AND DECONVOLUTION STRATEGY FOR LARGE SCALE SCREENING |
摘要 |
Embodiments of the present invention provide methods, systems, kits, and apparatus for data analysis to detect interactions between atoms, molecules and/or cells. One embodiment of the present invention provides for a novel pooling-deconvolution strategy that can dramatically decrease the effort required to generate large-scale data sets. This "PI-Deconvolution" strategy employs an N-digit base-X imaginary coding of XN probe proteins (baits or preys) and allows the screening of the baits in X*N pools, with N replicates for each bait. Deconvolution of proteins with their binding partners can be achieved by reading the prey's profile from the X*N experiments. The method can be used to screen XN bait or prey proteins. |
申请公布号 |
WO2007098130(A3) |
申请公布日期 |
2008.11.06 |
申请号 |
WO2007US04313 |
申请日期 |
2007.02.16 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;PURDUE RESEARCH FOUNDATION;HUANG, JING;JIN, FULAI;HAZBUN, TONY R. |
发明人 |
HUANG, JING;JIN, FULAI;HAZBUN, TONY R. |
分类号 |
G06F19/00 |
主分类号 |
G06F19/00 |
代理机构 |
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代理人 |
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地址 |
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