PHARMACODYNAMIC HYBRIDS ENDOWED OF HYPOGLYCEMIC AND NO-DONOR ACTIVITIES OBTAINED COMBINING HYDROXYLATED DERIVATIVES OF GLIBENCLAMIDE AND NITROOXY-SUBSTITUTED CARBOXYLIC ACIDS

摘要

Compound featuring a hypoglycemic action and in the meantime a release of nitric oxide (NO), said compound having the following general formula (I) : where at least one among R, R1, and R2 is a substitute comprising an nitroxy-ester group bound to a acyl aliphatic, aromatic or aliphatic-aromatic group. The compound can be in particular, used to treat patients affected by NO endogenous deficit responsive to diabetes mellitus of type 2.