发明名称 |
PIPERAZINYL-PROPYL-PYRAZOLE DERIVATIVES AS DOPAMINE D4 RECEPTOR ANTAGONISTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
摘要 |
The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder. |
申请公布号 |
WO2008108517(A3) |
申请公布日期 |
2008.11.06 |
申请号 |
WO2007KR03415 |
申请日期 |
2007.07.13 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;KONG, JAE YANG;PARK, WOO-KYU;CHO, HEEYEONG;JEONG, DAEYOUNG;CHOI, GILDON;KOH, HUN YEONG;KIM, SANG HEE;PAE, AE NIM;CHO, YONG SEO;CHA, JOO HWAN;CHOO, HYUNAH;CHAE, SANG EUN;LEE, HEE-YOON |
发明人 |
KONG, JAE YANG;PARK, WOO-KYU;CHO, HEEYEONG;JEONG, DAEYOUNG;CHOI, GILDON;KOH, HUN YEONG;KIM, SANG HEE;PAE, AE NIM;CHO, YONG SEO;CHA, JOO HWAN;CHOO, HYUNAH;CHAE, SANG EUN;LEE, HEE-YOON |
分类号 |
C07D401/06 |
主分类号 |
C07D401/06 |
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