摘要 |
A method of diagnosing, monitoring or imaging a neurodegenerative disease in an individual the method comprising measuring the levels of one or more components of the MEK5/ERK5/MEF module, or an activator of the MEK5/ERK5/MEF module, or the level of one or more components of the MEK3/p38 MAPK module, in a sample of body fluid or tissue from the individual. A method of detecting compounds useful for the diagnosis, monitoring, imaging or treatment of neurodegenerative disease comprising contacting a test compound with a member of the MEK5/ERK5/MEF module and assaying for an increase in the activity of the MEK5/ERK5/MEF module. Use of a component of the MEK5/ERK5/MEF module or an activator of the MEK5/ERK5/MEF module or the MEK3/p38 MAPK module in a method of detecting compounds useful for the diagnosis, monitoring, imaging or treatment of neurodegenerative disease. |
申请人 |
THE UNIVERSITY OF NOTTINGHAM;MAYER, JOHN, R.;CHAN, WENG, CHOON;REZVANI, ZAHRA, NOOSHIN |
发明人 |
MAYER, JOHN, R.;CHAN, WENG, CHOON;REZVANI, ZAHRA, NOOSHIN |