Compositions and methods for identifying modulators of sortilin are described. The methods are particularly useful for identifying analytes that antagonize sortilin s effect on processing of amyloid precursor protein to Aß peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.
申请公布号
WO2008076262(A3)
申请公布日期
2008.11.06
申请号
WO2007US25331
申请日期
2007.12.11
申请人
MERCK & CO., INC.;GETTY, KRISTA, L.;RAY, WILLIAM, J.;PAWELETZ, CLOUD, P.
发明人
GETTY, KRISTA, L.;RAY, WILLIAM, J.;PAWELETZ, CLOUD, P.