| 摘要 |
Disclosed is a compound useful as a prophylactic or therapeutic agent for a sex hormone-dependent disease or the like. Specifically disclosed are: a fused heterocyclic derivative represented by the general formula (I) and hav ing a GnRH antagonistic activity; a pharmaceutical composition comprising th e derivative; use of the pharmaceutical composition for medical purposes; an d others. In the formula (I), the ring A represents a 5-membered cyclic unsa turated hydrocarbon or a 5-membered cyclic heteroaryl; RA represents a halog en, an alkyl, an alkenyl, an alkynyl, a carboxy, an alkoxy, a carbamoyl, an alkylcarbamoyl or the like; the ring B represents an aryl or a hateroaryl; R B represents a halogen, an alkyl, a carboxy, an alkoxy, a carbamoyl, an alky lcarbamoyl or the like; E1 and E2 independently represents an oxygen atom or the like; Q represents a hydrogen atom, an alkyl, an alkylsulfonyl, an acyl or the like; X represents a group represented by the formula: -(alkylene)-Z , -CO-Y, -SO2-Y or the like (wherein Y represents Z, an amino or the like; a nd Z represents a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl or t he like) or the like.
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