GALACTOSE-PRONGED POLYSACCHARIDES IN A FORMULATION FOR ANTIFIBROTIC THERAPIES

摘要

Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific Io intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin: (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor: (vi) alpha 1-smooth muscle actin; (vii) matrix metalioproteinases MMP 2 and MMP9; (viii) matrix rnetalloprotemase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-ß1; (xi) endothelin receptor antagonists: and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.