METHOD FOR MAKING A POLYSACCHARIDE DIALDEHYDE HAVING HIGH PURITY

摘要

A method for making polysaccharide dialdehydes is disclosed, which uses a combination of precipitation and separation steps to purify the polysaccharide dialdehyde formed by oxidation of a polysaccharide with periodate. The method is simple, rapid, and provides a polysaccharide dialdehyde having very low levels of iodine-containing species. The polysaccharide dialdehyde is particularly suitable for preparing hydrogel adhesives for medical applications.