| 摘要 |
<p>This present disclosure provides compositions comprising E-10-0H-NT metabolites of AT and NT, methods for their synthesis and methods for their use In one embodiment, the compound (-)-E-5-(y-bromo?ropylidene)-10,11-d?hydro-IO-hydroxy-5H-dibenzo[a,d]- cycloheptene. Is prepared by reducing E-5-(y-bromopropylidene)-10,11d?hydro-IO-oxo-5H-d?benzo[a,d] ?cycloheptene in the presence of a crural-specific oxazaborolidine catalyst In another embodiment, method for inhibiting uptake of norepinephrine comprising contacting a norepinephrine transporter with a composition comprising E-IO-OH-NT that is enriched in the (-) enantiomer Is described</p> |
