Process for Production of (4,5-Dihydroisoxazol-3-Yl) Thio-Carboxamidine Salts

摘要

To provide a method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound simply, safely and in good yield, whereby drawbacks of prior art have been solved. A method for producing a (4,5-dihydroisoxazol-3-yl)thiocarboxamidine salt compound of the formula (2): wherein each of R¹ and R² which are independent of each other, is a hydrogen atom, an alkyl group or a cycloalkyl group, each of R³ and R⁴ which are independent of each other, is a hydrogen atom or an alkyl group, provided that R¹ and R², or R² and R³, may be bonded to each other to form a cycloalkyl group together with the carbon atoms to which they are bonded, and X² is a halogen or an anionic residue derived from an acid, which comprises reacting a 3-halogeno-4,5-dihydroisoxazole compound of the formula (1): wherein R¹, R², R³ and R⁴ are as defined above, and X¹ is a halogen, with thiourea in the presence of an acid.