ENGINEERED CONDUCTIVE POLYMER FILMS TO MEDIATE BIOCHEMICAL INTERACTIONS

摘要

The conductive polymer films of this disclosure reversibly and selectively mediate ligand-receptor interactions. This electrochemical manipulation of biochemical interactions is accomplished by embedding or adsorbing receptors for ligands of interest in or onto a conductive polymer matrix. The matrix can also be doped, for example, with desired ions, polyions, or surfactants. Depending on the receptor properties and dopants utilized, ligand-receptor interactions at the polymer-electrolyte interface are manipulated by controlling the oxidation and reduction of the conductive polymer. The intrinsic charge transfer characteristics of conductive polymers are used to modulate ligand-receptor interactions.