摘要 |
<p>An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P 1 ), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below
(where A represents an oxygen atom, a sulfur atom, a group represented by Formula -SO-, a group represented by Formula -SO 2 -, or the like, R 1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, R 1A represents a hydrogen atom or the like, R 2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, R 3 represents an aryl group, R 4 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and R 5 represents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).</p> |
申请人 |
TAISHO PHARMACEUTICAL CO. LTD. |
发明人 |
ONO, NAOYA;TAKAYAMA, TETSUO;SHIOZAWA, FUMIYASU;KATAKAI, HIRONORI;YABUUCHI, TETSUYA;OTA, TOMOMI;YAGI, MAKOTO;SATO, MASAKAZU |