METHODS AND COMPOSITIONS FOR THE CORRELATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE VITAMIN K EPOXIDE REDUCTASE GENE AND WARFARIN DOSAGE

摘要

The present invention provides a host cell comprising a heterologous nucleic acid encoding a vitamin K epoxide reductase (VKOR) and a nucleic acid encoding a vitamin K dependent protein, wherein the nucleic acids encoding both the VKOR and Vitamin K dependent protein are expressed in said host cell. The invention also provides methods for improving the productivity of vitamin K dependent protein expression in a host cell.