| 摘要 |
<p>This invention relates to a process for producing optically active alcohols using asymmetric reduction of aromatic ketones. This process gives optically active alcohols in high enantioselectivity at large scale production. Aromatic ketones represented by formula (I)
[wherein, R 1 are selected from hydrogen atom, halogen atom, lower alkyl group etc. R 2 is -(CH 2 )n-R 3 [wherein, n is 1 to 5 integer. R 3 are selected from hydrogen atom, halogen atom, lower alkoxycarbonyl group etc. and formula (II) and (III).
{wherein, R 4 is selected from lower alkyl group (1 to 5 carbon atom) etc. R 5 and R 6 are the same or different and are selected from hydrogen atom, halogen atom, lower alkyl group etc.}]] are reduced by sodium borohydride, chlorotrimethylsilane and optically active 2-[bis(4-methoxyphenyl)hydroxymethyl]pyrrolidine represented by formula (IV)
to give optically active alcohol represented by formula (V) stereoselectively.
(wherein, R 1 and R 2 are as defined above.)</p> |
