发明名称 |
A process for the preparation of olanzapine |
摘要 |
<p>The invention relates to the process for the preparation of antipsychotic medicament olanzapine which comprises the reaction of anhydrous piperazine with 4-amino-2-methyl-10H-thieno[2.3- b ][1.5]-benzodiazepine or its inorganic acid addition salt carried out in molten piperazine in the absence of a solvent, and then N-methylation of N-demethylolanzapine thus obtained to form olanzapine.</p> |
申请公布号 |
EP1988092(A1) |
申请公布日期 |
2008.11.05 |
申请号 |
EP20080161324 |
申请日期 |
2005.11.15 |
申请人 |
ADAMED SP. Z O.O. |
发明人 |
RECHNIO, JUSTYNA;STAWINSKI, TOMASZ;MAJKA, ZBIGNIEW |
分类号 |
C07D495/04 |
主分类号 |
C07D495/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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