COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
摘要
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product includes collagenase I and collagenase II in a ratio of about 1 to 1, with a purity of greater than at least 95%. The invention further disclosed improved fermentation and purification processes for preparing the said drug product.
申请公布号
EP1987141(A2)
申请公布日期
2008.11.05
申请号
EP20070762860
申请日期
2007.01.30
申请人
AUXILIUM INTERNATIONAL HOLDINGS, INC.
发明人
SABATINO, GREGORY, L.;DEL TITO, JR., BENJAMIN, J.;BASSETT, PHILLIP, J.;THARIA, HAZEL, A.;HITCHCOCK, ANTONY, G.;YU, BO;WEGMAN, THOMAS L.