发明名称 |
Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
摘要 |
Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.
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申请公布号 |
US7445916(B2) |
申请公布日期 |
2008.11.04 |
申请号 |
US20050104349 |
申请日期 |
2005.04.12 |
申请人 |
WYETH |
发明人 |
GU JIANXIN;CAI PING;RUPPEN MARK E. |
分类号 |
C12P17/16;C07D498/18;C12P17/10;C12P17/18 |
主分类号 |
C12P17/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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