| 发明名称 |
TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES |
| 摘要 |
<p>Compounds of formula (I) are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.</p> |
| 申请公布号 |
SI20691(B) |
申请公布日期 |
2008.10.31 |
| 申请号 |
SI20000020013 |
申请日期 |
2000.01.10 |
| 申请人 |
AGOURON PHARMACEUTICALS, INC.;CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
WEBBER STEPHEN EVAN;CANAN-KOCH STACIE S.;TIKHE JAYASHREE GIRISH;THORESEN LARS HENRIK |
| 分类号 |
A61K;A61K31/437;A61K31/4375;A61K31/55;A61K31/551;A61P;A61P3/10;A61P9/10;A61P25/28;A61P29/00;A61P35/00;A61P43/00;C07D;C07D209/00;C07D221/00;C07D223/00;C07D243/00;C07D471/06;C07D487/00;C07D487/06;C07D519/00 |
主分类号 |
A61K |
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