SALES DE ADICION DE ACIDO, HIDRATOS Y POLIMORFOS DE ETIL-AMIDA DEL ACIDO 5-(2,4-DIHIDROXI-5-ISOPROPIL-FENIL)-4-(4-MORFOLIN-4-IL-METIL-FENIL)-ISOXAZOL-3-CARBOXILICO, Y FORMULACIONES QUE COMPRENDEN ESTAS FORMAS

摘要

The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.