INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR MEDIATING OR INHIBITING CELLL PROLIFERATION

摘要

INDAZOLE COMPOUNDS THAT MODULATE AND/OR INHIBIT CELL PROLIFERATION, SUCH AS THE BACTIVITY OF PROTEIN KINASES ARE DESCRIBED. THESE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEN ARE CAPABLE OF MEDIATING, E.G., KINASES-DEPENDENT DISEASES TO MODULATE AND/OR INHIBIT UNWANTED CELL PROLIFERATION. THE INVENTION IS ALSO DIRECTED TO THE THERAPEUTIC OR PROPHYLACTIC USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND TO METHODS OF TREATING CANCER AS WELL AS OTHER DISEASE STATES ASSOCIATED WITH UNWANTED ANGIOGENESIS AND/OR CELLULAR PROLIFERATION, SUCH AS DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, RHEUMATOID ARTHRITIS, AND PSORIASIS, BY ADMINISTERING EFFECTIVES AMOUNTS OF SUCH COMPOUNDS.