发明名称 |
Variants of Group 1 Allergens from Poaceae Having Reduced Allergenicity and Maintained T-Cell Reactivity |
摘要 |
The present invention relates to the preparation and use of variants of the group 1 allergens of the Poaceae (sweet grasses) which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially maintained reactivity with T-lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventive immunotherapy of grass pollen allergies.
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申请公布号 |
US2008267985(A1) |
申请公布日期 |
2008.10.30 |
申请号 |
US20050572370 |
申请日期 |
2005.07.11 |
申请人 |
MERCK PATENT GMBH |
发明人 |
FIEBIG HELMUT;WALD MARTIN;NANDY ANDREAS;KAHLERT HELGA;WEBER BERNAHRD;CROMWELL OLIVER |
分类号 |
A61K39/35;A61K31/711;C07H21/04;C07K14/415;C12N1/20;C12N15/00;C12P21/06 |
主分类号 |
A61K39/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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