| 摘要 |
The present invention encompasses a model-based method for determining in sulin sensitivity and glucose absorption from oral glucose tolerance tests o r mixed meals. The present invention has several advantages over current met hods. The technique requires about four to six blood samples taken over abou t two to three hours following glucose ingestion and is therefore applicable to large-scale clinical trials. The analysis involves a reduced version of the classical minimal model, a method for describing glucose absorption usin g only two parameters, and an integral approach enabling the parameters to b e obtained using simple algebra. The present method robustly identifies diff erences in insulin sensitivity in different patient types as well as improve ments in insulin sensitivity arising from pharmaceutic therapy. In addition, insulin sensitivity measurements obtained with the present method are highl y correlated with results from hyperinsulinemic clamps (r2> 0.8). This me thod is therefore a practical and robust method for determining insulin sens itivity under physiologic conditions.
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