发明名称 |
METHODS OF TREATING CANCER BY INTERFERING WITH IGF-I RECEPTOR SIGNALING |
摘要 |
The invention includes methods of reducing proliferation, causing apoptosis and treating cancer through the inhibition of ASM, the disruption of lipid rafts and the interference with IGF-IR and Racl signaling using a variety of compounds including siRNA, anti-ASM antibodies, anti-ceramide antibodies, short- chain ceramide derivatives, desipramine, clomipramine, mangostin and/or sphingomyelin substrate analogues. |
申请公布号 |
WO2008112297(A3) |
申请公布日期 |
2008.10.30 |
申请号 |
WO2008US03393 |
申请日期 |
2008.03.13 |
申请人 |
YALE UNIVERSITY;NEVADA CANCER INSTITUTE;SUN, HONG;GHOSH, PAPIA;KIM, YONGSOON |
发明人 |
SUN, HONG;GHOSH, PAPIA;KIM, YONGSOON |
分类号 |
C12N5/16;C12N15/113 |
主分类号 |
C12N5/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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